microsoft office excel cannot access the file there are several possible reasons

  1. Create directory “C:\Windows\SysWOW64\config\systemprofile\Desktop ” (for 64 bit Windows) or “C:\Windows\System32\config\systemprofile\Desktop ” (for 32 bit Windows)
  2. Set Full control permissions for directory Desktop (for example in Win7 & IIS 7 & DefaultAppPool set permissions for user “IIS AppPool\DefaultAppPool”)
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